Sofosbuvir + Velpatasvir + Voxilaprevir, Indication, Dosage, Side Effect

Indication:

This combination is used to treat chronic hepatitis C virus (HCV) infection in adults who have previously failed treatment with certain direct-acting antivirals (DAAs), including NS5A inhibitors. It is especially helpful for people with genotypes 1 through 6, making it a pan-genotypic option. It works by targeting three different proteins the virus needs to survive—Sofosbuvir blocks viral replication, Velpatasvir stops viral assembly, and Voxilaprevir blocks viral maturation—giving it powerful effectiveness against resistant strains of the virus.

Dosage:                               

This fixed-dose combination tablet is used for treating chronic hepatitis C in patients who have failed prior antiviral treatments. The standard dosage for adults is one tablet once daily, containing Sofosbuvir 400 mg, Velpatasvir 100 mg, and Voxilaprevir 100 mg, taken with food to improve absorption. It is typically given for 12 weeks and is mainly used in patients who have previously been treated with a direct-acting antiviral (DAA) and did not respond, including those with or without compensated cirrhosis.

Note:

Not recommended for patients with decompensated liver disease.

Should be taken at the same time each day for consistency.

Hepatitis B screening is important before starting due to reactivation risk.

Regular monitoring of liver function and viral load is required during treatment.

Side Effect:

The most common side effects of SOFOSBUVIR + VELPATASVIR + VOXILAPREVIR are:     

Dizziness, tiredness, diarrhea, cough. Tell your doctor or pharmacist right away if any of these side effects persist or worsen.

Remember that your doctor has prescribed this medication because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: unexplained muscle pain/tenderness/weakness.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times on the days your doctor directs.

This is not a complete list of possible side effects. Contact your doctor or pharmacist if you have any other side effects not listed above.

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Sofosbuvir + Velpatasvir + Voxilaprevir has different brand names depending on the manufacturer. Some of the brand names are: