Sacubitril + Valsartan: Indication, Dosage, Side Effect

Indication:

Sacubitril + Valsartan is mainly used to treat heart failure with reduced ejection fraction (HFrEF) in adults. This condition means the heart isn’t pumping blood as strongly as it should. Sacubitril helps relax blood vessels and reduce fluid buildup by increasing protective substances, while Valsartan blocks harmful effects of certain hormones that raise blood pressure and strain the heart. Together, they improve heart function, lower the risk of hospitalization, and help patients live longer by easing symptoms like shortness of breath, fatigue, and swelling.

Dosage:                               

Sacubitril + Valsartan is a combination medicine used to treat heart failure with reduced ejection fraction (HFrEF). The typical starting dose is 49 mg sacubitril / 51 mg valsartan twice daily, but for patients who are new to this type of treatment or have low blood pressure or kidney problems, doctors may start with a lower dose, like 24 mg / 26 mg twice daily. After 2–4 weeks, the dose is usually increased to the target of 97 mg / 103 mg twice daily, as tolerated. This helps the heart work more efficiently and reduces the risk of hospitalization or death.

Note:

Must stop ACE inhibitors 36 hours before starting this medicine to avoid serious side effects.

Take with or without food at the same times each day.

Regular blood pressure, kidney function, and potassium levels should be monitored.

Side Effect:

The most common side effects of SACUBITRIL + VALSARTAN are:

Cough, lightheadedness, dizziness. Tell your doctor or pharmacist right away if any of these side effects persist or worsen.

Remember that your doctor has prescribed this medication because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine), symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), fainting.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times on the days your doctor directs.

This is not a complete list of possible side effects. Contact your doctor or pharmacist if you have any other side effects not listed above.

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SACUBITRIL+VALSARTAN has different brand names depending on the manufacturer. Some of the brand names are: