Regorafenib: Indication, Dosage, Side Effect
Indication:
Regorafenib is used to treat certain advanced or metastatic cancers that have stopped responding to other treatments. These include colorectal cancer, gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (liver cancer). It works by blocking multiple proteins (kinases) that help cancer cells grow and form new blood vessels. By targeting these pathways, regorafenib helps slow down tumor growth and spread, especially when other therapies are no longer effective.
Dosage:
Regorafenib is usually prescribed at a dose of 160 mg once daily, taken for 21 days, followed by 7 days off, in a 28-day treatment cycle. It comes as 40 mg tablets, so patients typically take four tablets at once, with a low-fat meal at the same time each day. It’s used for cancers like colorectal cancer, gastrointestinal stromal tumors (GIST), and liver cancer. The doctor may adjust the dose based on how well the patient tolerates it, as it can cause side effects like fatigue, hand-foot skin reaction, or high blood pressure.
Extra Notes:
Always take with a low-fat meal to reduce side effects and improve absorption.
Do not crush or chew the tablets—swallow them whole.
Dose may be lowered or paused if side effects become too strong.
Regular check-ups and blood tests are important during treatment.
Side Effect:
The most common side effects of Regorafenib are:
Diarrhea, pain/sores in the mouth/throat, changes in taste, dry mouth, loss of appetite, hair loss, voice changes, weight loss, or muscle stiffness. Tell your doctor or pharmacist right away if any of these side effects persist or worsen.
Remember that your doctor has prescribed this medication because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: slow wound healing, signs of dehydration (such as extreme thirst, dizziness, decreased urination), signs of mineral imbalance (such as muscle cramps/weakness, irregular heartbeat, mental/mood changes), signs of infection (such as fever, chills, persistent sore throat), signs of underactive thyroid (weight gain, cold intolerance, unusual tiredness, slow heartbeat).
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times on the days your doctor directs.
This is not a complete list of possible side effects. Contact your doctor or pharmacist if you have any other side effects not listed above.
FAQ:
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Regorafenib has different brand names depending on the manufacturer. Some of the brand names are:
