Dacomitinib: Indication, Dosage, Side Effect
Indication:
Dacomitinib is an oral medication used to treat metastatic non-small cell lung cancer (NSCLC) in adults whose tumors have specific mutations in the epidermal growth factor receptor (EGFR) gene, namely exon 19 deletions or exon 21 L858R substitutions. These mutations lead to uncontrolled cell growth and are present in approximately 10–35% of NSCLC cases globally.
As a second-generation EGFR tyrosine kinase inhibitor (TKI), dacomitinib irreversibly blocks the activity of EGFR and related proteins (HER2 and HER4), which are involved in cancer cell proliferation. This inhibition helps to slow down or stop the growth of tumors harboring these mutations.
Dacomitinib is typically used as a first-line treatment for patients with EGFR mutation-positive metastatic NSCLC who have not received prior systemic therapy. It has shown superior progression-free survival compared to gefitinib in clinical trials. However, it is not recommended for patients who have previously been treated with other EGFR TKIs, such as afatinib, due to potential overlapping toxicities and lack of additional benefit.
Dosage:
Dacomitinib is an oral medication used to treat metastatic non-small cell lung cancer (NSCLC) with specific mutations in the epidermal growth factor receptor (EGFR), namely exon 19 deletions or exon 21 L858R substitutions. The standard dosage is 45 mg once daily, taken with or without food. It's important to take the tablet whole—do not chew, crush, or break it—and aim to take it at the same time each day to maintain consistent drug levels. If you miss a dose or vomit after taking it, do not take an additional dose; simply continue with your next scheduled dose.
Extra Notes:
Always follow your doctor's instructions regarding the use of dacomitinib. If you have any questions or concerns about your treatment, consult your healthcare provider.
Side Effect:
The most common side effects of Dacomitinib are:
Weight loss, mouth sores, decreased appetite, swelling or infection around your nails, or dry skin. Diarrhea is a common side effect. Drink plenty of fluids as directed by your doctor to lessen your risk of dehydration.
Remember that your doctor has prescribed this medication because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Your doctor may prescribe anti-diarrhea medication (such as loperamide) to control your symptoms. Tell your doctor right away if you have: diarrhea that doesn't stop or is severe, signs of dehydration (such as unusual decreased urination, unusual dry mouth/thirst, fast heartbeat, dizziness/lightheadedness).
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times on the days your doctor directs.
This is not a complete list of possible side effects. Contact your doctor or pharmacist if you have any other side effects not listed above.
FAQ:
Frequently Asked Questions Regarding (DACOMITINIB) / Generic VIZIMPRO DACOMITINIB:
May I inquire about the availability of the generic form of DACOMITINIB, commonly referred to as/ VIZIMPRO, for global distribution?
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DACOMITINIB has different brand names depending on the manufacturer. Some of the brand names are:
