Repaglinide + Metformin Hydrochloride: Indication, Dosage, Side Effect
Indication:
Repaglinide + metformin hydrochloride is used to help control blood sugar levels in adults with type 2 diabetes when diet, exercise, or single medications aren’t enough. This combination works in two ways: repaglinide increases insulin release from the pancreas to lower blood sugar after meals, while metformin reduces sugar production in the liver and helps the body use insulin more effectively. Together, they help manage diabetes and reduce the risk of complications like nerve damage, kidney problems, and heart disease.
Dosage:
The dosage of repaglinide + metformin hydrochloride depends on the patient's blood sugar levels, previous diabetes treatment, and how well they tolerate the medicine. A common starting dose is 1 mg repaglinide / 500 mg metformin, taken twice daily with meals. The dose may be adjusted gradually based on blood sugar control, but it should not exceed 10 mg repaglinide and 2500 mg metformin per day. This combination helps lower blood sugar by increasing insulin release (repaglinide) and reducing sugar production and absorption (metformin).
Extra Notes:
Always take with meals to reduce the risk of low blood sugar and stomach upset.
Do not skip meals while on this medication.
Monitor blood sugar regularly and follow your doctor’s dose adjustments.
Watch for signs of low blood sugar (dizziness, sweating, hunger) and lactic acidosis (muscle pain, weakness, tiredness).
Side Effect:
The most common side effects of REPAGLINIDE + METFORMIN HYDROCHLORIDE are:
Diarrhea, nausea, and upset stomach. Tell your doctor or pharmacist right away if any of these side effects persist or worsen.
Remember that your doctor has prescribed this medication because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
tell your doctor or pharmacist promptly. If stomach symptoms return later (after you are on the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be a sign of lactic acidosis.
Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times on the days your doctor directs.
This is not a complete list of possible side effects. Contact your doctor or pharmacist if you have any other side effects not listed above.
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Repaglinide + Metformin Hydrochloride has different brand names depending on the manufacturer. Some of the brand names are:
